Bioengineered human vascular network

Research Overview

Stem cells and tissue engineering hold great promise in Regenerative Medicine. However, engrafting stem cells and generating tissues with stable functional vascular beds remain major challenges. Our laboratory uses bioengineering principles to understand how vascular networks are formed and  the mechanisms by which the vasculature modulates the engraftment and activity of various human stem cells.

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Selected Publications

Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks
Lin RZ, Lee CN, Moreno-Luna R, Neumeyer J, Piekarski B, Zhou P, Moses MA, Sachdev M, Pu WT, Emani S,  Melero-Martin JM
Nat Biomed Eng 2017; 1:0081 | Editorial Commentary | Editorial News and Views | Behind the paper
PDF | Supplementary Information


Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling
Lin RZ, Moreno-Luna R, Li D, Jaminet SCS, Greene AK, Melero-Martin JM
Proc Natl Acad Sci USA 2014; 111(28):10137-10142


Transdermal regulation of vascular network bioengineering using a photopolymerizable methacrylated gelatin hydrogel
Lin RZ, Chen YC, Moreno-Luna R, Khademhosseini A, Melero-Martin JM
Biomaterials 2013; 34(28):6785-96


Functional human vascular network generated in photocrosslinkable gelatin methacrylate hydrogels
Chen YC*, Lin RZ*, Qi H, Yang Y, Bae H, Melero-Martin JM, Khademhosseini A (*co-first authors)
Adv Funct Mater 2012; 22(10):2027-39


Induction of erythropoiesis using human vascular networks genetically-engineered for controlled erythropoietin release
Lin RZ, Dreyzin A, Aamodt K, Li D, Jaminet SC, Dudley AC, Melero-Martin JM
Blood 2011; 118(20):5420-8

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