The ability to bioengineer vasculature creates the possibility to introduce additional instructions into tissues by genetically modifying the endothelial cells that will actually build these blood vessels. We are developing models that use genetically-engineered ECFCs to achieve controlled administration of therapeutic proteins in vivo.
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Key publications
Bioengineering hemophilia A-specific microvascular grafts for delivery of full-length factor VIII into the bloodstream
Neumeyer J, Lin RZ, Wang K, Hong X, Hua T, Croteau SE, Neufeld EJ, Melero-Martin JM
Blood Adv 2019; 3(24):4166-4176
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Induction of erythropoiesis using human vascular networks genetically-engineered for controlled erythropoietin release
Lin RZ, Dreyzin A, Aamodt K, Li D, Jaminet SC, Dudley AC, Melero-Martin JM
Blood 2011; 118(20):5420-8
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Adventures in gene therapy: Getting your own blood vessels to make drugs
Melero-Martin JM
VECTOR blog, June 18, 2014.