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Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks
Lin RZ, Lee CN, Moreno-Luna R, Neumeyer J, Piekarski B, Zhou P, Moses MA, Sachdev M, Pu WT, Emani S,  Melero-Martin JM
Nat Biomed Eng 2017; 1:0081
PDF | Supplementary Information | Editorial Commentary | Editorial News and Views | Behind the paper


Endothelial colony forming cells and mesenchymal progenitor cells form blood vessels and increase blood flow in ischemic muscle
Kang KT, Lin RZ, Kuppermann D,  Melero-Martin JM, Bischoff J.
Sci Rep 2017; 7(1):770


Endothelial Progenitors: a consensus statement on nomenclature
Medina RJ, Barber CL, Dignat-George F, Melero-Martin JM, Khosrotehrani K, Ohneda O, Randi AM, Chan JKY, Yamaguchi T, van Hinsbergh V, Yoder MC, Stitt AW.
Stem Cell Transl Med 2017; 6(5):1316-20


VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis
Chen J, Fu Y, Day DS, Sun Y, Wang SY, Liang X, Gu F, Zhang F, Stevens SM, Zhou PZ, Li K, Zhang Y, Lin RZ, Smith LEH, Zhang J, Sun K, Melero-Martin JM, Han ZG, Park PJ, Zhang B, Pu WT.
Nat Commun 2017; 8(1):383


Elastomeric fibrous hybrid scaffold supports in vitro and in vivo tissue formation
Masoumi N, Cooper DA, Chen P, Cubberley A, Guo K, Lin RZ, Bayoumi A, Martin D, Aikawa E,  Melero-Martin JM, Mayer JE Jr.
Adv Funct Mater 2017; in press


Devitalized stem cell microsheets for sustainable release of osteogenic and vasculogenic growth factors and regulation of anti-inflammatory immune response
Moeinzadeh S, Shariati SR, Kader S,  Melero-Martin JM, Jabbari E.
Adv Biosystems 2017; in press



Spatiotemporal release of BMP-2 and VEGF enhances osteogenic and vasculogenic differentiation of human mesenchymal stem cells and endothelial colony-forming cells co-encapsulated in a patterned hydrogel
Barati D, Shariati SR, Moeinzadeh S, Melero-Martin JM, Khademhosseini A, Jabbari E.
J Control Release 2016; 223:126-36



Microfluidic capture of endothelial colony-forming cells from human adult peripheral blood: phenotypic and functional validation in vivo
Lin RZ, Hatch A, Antontsev VG, Murthy SK, Melero-Martin JM
Tissue Eng Part C Methods 2015; 21(3):274-83


Bioengineering vascularized tissue constructs using an injectable cell-laden enzymatically crosslinked collagen hydrogel derived from dermal extracellular matrix
Kuo KC, Lin RZ, Tien HW, Wu PY, Li YC, Melero-Martin JM, Chen YC
Acta Biomater 2015; Nov;27:151-166


Enzymatic regulation of functional vascular networks using gelatin hydrogels
Chuang CH, Lin RZ, Tien HW, Chu YC, Li YC, Melero-Martin JM, Chen YC
Acta Biomater 2015; Jun;19:85-99



Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling
Lin RZ, Moreno-Luna R, Li D, Jaminet SCS, Greene AK, Melero-Martin JM.
Proc Natl Acad Sci USA 2014; 111(28):10137-10142


Decreased level of cord blood circulating endothelial colony-forming cells in preeclampsia
Muñoz-Hernandez R, Miranda M, Stiefel P, Lin RZ, Praena-Fernandez J, Dominguez-Simeon M, Villar J, Moreno-Luna R, Melero-Martin JM
Hypertension 2014; 64(1):165-171 – Editorial commentary


Maternal body-mass index and cord blood circulating endothelial colony-forming cells
Moreno-Luna R*, Muñoz-Hernandez R*, Lin RZ, Miranda ML, Vallejo-Vaz AJ, Stiefel P, Praena-Fernandez JM, Bernal-Bermejo J, Jimenez-Jimenez LM, Villar J, Melero-Martin JM (*co-first authors)
J Pediatr 2014; 164(3):566-71 – Editorial commentary


TM4SF1: a new vascular therapeutic target in cancer
Lin CL, Merley A, Sciuto TE, Li D, Dvorak AM, Melero-Martin JM, Dvorak HF, Jaminet SCS
Angiogenesis 2014; 17(4):897-907


Epicardium-to-fat transition in injured heart
Liu Q, Huang X, Oh JH, Lin RZ, Duan S, Yu Y, Yang R, Qiu J, Melero-Martin JM, Pu WT, Zhou B
Cell Res 2014; 24(11):1367-9


Vascular channels formed by subpopulations of PECAM+ melanoma cells
Dunleavey JM, Xiao L, Thompson J, Kim MM, Shields J, Shelton SE, Irvin DM, Brings BE, Ollila D, Brekken RA, Dayton PA, Melero-Martin JM, Dudley AC
Nat Commun 2014; Oct 22;5:5200



Transdermal regulation of vascular network bioengineering using a photopolymerizable methacrylated gelatin hydrogel
Lin RZ, Chen YC, Moreno-Luna R, Khademhosseini A, Melero-Martin JM
Biomaterials 2013; 34(28):6785-96


Human white adipose tissue vasculature contains endothelial colony-forming cells with robust in vivo vasculogenic potential
Lin RZ*, Moreno-Luna R*, Muñoz-Hernandez R, Li D, Jaminet SC, Greene AK, Melero-Martin JM (*co-first authors)
Angiogenesis 2013; 34(28):6785-96



Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cells
Lin RZ, Moreno-Luna R, Zhou B, Pu WT, Melero-Martin JM
Angiogenesis 2012; 15(3):443-55


Fibroblast growth factor-2 facilitates rapid anastomosis formation between bioengineered human vascular networks and living vasculature
Lin RZ, Melero-Martin JM
Methods 2012; 56(3):440-51


Functional human vascular network generated in photocrosslinkable gelatin methacrylate hydrogels
Chen YC*, Lin RZ*, Qi H, Yang Y, Bae H, Melero-Martin JM, Khademhosseini A (*co-first authors)
Adv Funct Mater 2012; 22(10):2027-39


Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes
Zhou B, Honor LB, Ma Q, Oh JH, Lin RZ, Melero-Martin JM, von Gise A, Zhou P, Hu T, He L, Wu KH, Zhang H, Zhang Y, Pu WT
J Mol Cell Cardiol 2012; 52(1):43-7


Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis
Wagner M, Bjerkvig R, Wiig H,  Melero-Martin JM, Lin RZ, Klagsbrun M, Dudley AC
Angiogenesis 2012; 15(3):481-95



Induction of erythropoiesis using human vascular networks genetically-engineered for controlled erythropoietin release
Lin RZ, Dreyzin A, Aamodt K, Li D, Jaminet SC, Dudley AC, Melero-Martin JM
Blood 2011; 118(20):5420-8


Bioengineering human microvascular networks in immunodeficient mice
Lin RZ, Melero-Martin JM
J Vis Exp 2011; Jul 11;(53).pii:3065


Concise review: vascular stem cells and tumor angiogenesis
Melero-Martin JM, Dudley AC
Stem Cells 2011; 29:163-8


Functional endothelial progenitor cells from cryopreserved umbilical cord blood
Lin RZ, Dreyzin A, Aamodt K, Dudley AC, Melero-Martin JM
Cell Transplant 2011; 20:515-522


Adult mouse epicardium modulates myocardial injury by secreting paracrine factors
Zhou B, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, Gise AV, Zhou P, Hu YW, Wang G, Zhang B, Wang L, Hall JL, Moses MA, McGowan FX, Pu WT
J Clin Invest 2011; 121:1894-1904


Type I collagen, fibrin and Puamatrix matrices provide permissive environments for human endothelial and mesenchymal progenitor cells to form neovascular networks
Allen P, Melero-Martin JM, Bischoff J
J Tissue Eng Regen Med 2011; Apr 5(4):e74-86



Host myeloid cells are necessary for creating bio-engineered human vascular networks in vivo
Melero-Martin JM, De Obaldia ME, Allen P, Dudley AC, Klagsbrun M, Bischoff J
Tissue Eng Part A 2010; 16:2457-2466

Bone marrow is a reservoir for pro-angiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors
Dudley AC, Udagawa T, Melero-Martin JM, Shih SC, Curatolo A, Moses M, Klagsbrun M
Blood 2010; 116:3367-3371

In vivo monitoring of autologous engineered pulmonary valve function
Gottlieb D, Tandon K, Emani S, Aikawa E, Brown DW, Powell AJ, Nedder A, Engelmayr GC, Melero-Martin JM, Sacks MS, Mayer JE Jr
J Thorac Cardiovasc Surg 2010; 139:723-731

Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study
Hjortnaes J, Gottlieb D, Figueiredo JL, Melero-Martin JM, Kohler RH, Bischoff J, Weissleder R, Mayer, J, Aikawa E
Tissue Eng Part C Methods 2010; 16:597-607

Methodology for optimal in vitro cell expansion in tissue engineering
Melero-Martin JM, Santhalingam S, Al-Rubeai M
Adv Biochem Eng Biotechnol 2009; 112:209-29

Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells
Melero-Martin JM, De Obaldia ME, Kang S-Y, Khan ZA, Yuan L, Oettgen P, Bischoff J
Circ Res 2008; 103:194-202. Editorial commentary  –  Best paper award 2009

Chapter 13: An in vivo experimental model for postnatal vasculogenesis
Melero-Martin JM, Bischoff J
Methods Enzymol 2008; 445:303-329

Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice
Khan ZA*, Boscolo E*, Picard A, Psutka S, Melero-Martin JM, Bartch TC, Mulliken JB, Bischoff J
J Clin Invest 2008; 118: 2592-2599

In vivo vasculogenic potential of human blood-derived endothelial progenitor cells
Melero-Martin JM, Khan ZA, Picard A, Wu X, Paruchuri S, Bischoff J
Blood 2007; 109:4761-4768

Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2
Paruchuri S, Yang JH, Rabkin-Aikawa E, Melero-Martin JM, Khan ZA, Loukogeorgakis S, Schoen FJ, Bischoff J
Circ Res 2006; 99:861-869

Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to Endostatin
Khan ZA, Melero-Martin JM, Wu X, Paruchuri S, Boscolo E, Mulliken JB, Bischoff J
Blood 2006; 108:915-921

Expansion of chondroprogenitor cells on macroporous microcarriers as an alternative to conventional monolayer systems
Melero-Martin JM, Dowling MA, Smith M, Al-Rubeai M
Biomaterials 2006; 27:2970-2979

Optimal in-vitro expansion of chondroprogenitor cells in monolayer culture
Melero-Martin JM, Dowling MA, Smith M, Al-Rubeai M
Biotechnol Bioeng 2006; 93:519-533

Cryopreservation and in-vitro expansion of chondroprogenitor cells isolated from the superficial zone of articular cartilage
Martin JM, Smith M, Al-Rubeai M
Biotechnol Prog 2005; 21:168-177