Research Overview
Stem cells and tissue engineering hold great promise in Regenerative Medicine. However, engrafting stem cells and generating tissues with stable functional vascular beds remain major challenges. Our laboratory uses bioengineering principles to understand how vascular networks are formed and the mechanisms by which the vasculature modulates the engraftment and activity of various human stem cells.
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Selected Publications
Mitochondrial transfer mediates endothelial cell engraftment through mitophagy
Lin RZ , Im GB, Luo AC, Zhu Y, Hong X, Neumeyer J, Tang HW, Perrimon N, Melero-Martin JM
Nature 2024;629(8012):660-668
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Robust differentiation of human pluripotent stem cells into mural progenitor cells via transient activation of NKX3.1
Lee U †, Zhang Y †, Zhu Y, Luo AC, Gong L, Tremmel DM, Kim Y, Villarreal VS, Wang X, Lin RZ, Cui M, Ma M, Yuan K, Wang K *, Chen K *, Melero-Martin JM *
Nat Commun 2024;15:8392
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Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA
Wang K, Lin RZ, Hong X, Ng AH, Lee CN, Neumeyer J, Wang G, Wang X, Ma M, Pu WT, Church GM, Melero-Martin JM
Sci Adv 2020;6(30):eaba7606
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Bioengineering hemophilia A-specific microvascular grafts for delivery of full-length factor VIII into the bloodstream
Neumeyer J, Lin RZ, Wang K, Hong X, Hua T, Croteau SE, Neufeld EJ, Melero-Martin JM
Blood Adv 2019;3(24):4166-4176
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Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks
Lin RZ, Lee CN, Moreno-Luna R, Neumeyer J, Piekarski B, Zhou P, Moses MA, Sachdev M, Pu WT, Emani S, Melero-Martin JM
Nat Biomed Eng 2017;1:0081 | Editorial Commentary | Editorial News and Views | Behind the paper
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Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling
Lin RZ, Moreno-Luna R, Li D, Jaminet SCS, Greene AK, Melero-Martin JM
Proc Natl Acad Sci USA 2014;111(28):10137-10142
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Transdermal regulation of vascular network bioengineering using a photopolymerizable methacrylated gelatin hydrogel
Lin RZ, Chen YC, Moreno-Luna R, Khademhosseini A, Melero-Martin JM
Biomaterials 2013;34(28):6785-96
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Functional human vascular network generated in photocrosslinkable gelatin methacrylate hydrogels
Chen YC*, Lin RZ*, Qi H, Yang Y, Bae H, Melero-Martin JM, Khademhosseini A (*co-first authors)
Adv Funct Mater 2012;22(10):2027-39
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Induction of erythropoiesis using human vascular networks genetically-engineered for controlled erythropoietin release
Lin RZ, Dreyzin A, Aamodt K, Li D, Jaminet SC, Dudley AC, Melero-Martin JM
Blood 2011; 118(20):5420-8
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